Chapter 15 - Nuclear Transfer Technology and Its Use in Reproductive Medicine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F21%3AN0000254" target="_blank" >RIV/00027014:_____/21:N0000254 - isvavai.cz</a>
Result on the web
<a href="https://vuzv.cz/_privat/21245.pdf" target="_blank" >https://vuzv.cz/_privat/21245.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/9781108887595" target="_blank" >10.1017/9781108887595</a>
Alternative languages
Result language
angličtina
Original language name
Chapter 15 - Nuclear Transfer Technology and Its Use in Reproductive Medicine
Original language description
This chapter focuses on the application of nuclear transfer for production of “artificial gametes”, through the haploidization of somatic cells transplanted into immature (germinal vesicle, GV) or mature (metaphase II) oocytes. Haploidization of somatic nuclei through their transfer into oocytes from human, or model mammals has been attempted already with predominantly negative outcomes. In this chapter we critically review the published reports on the topic, with the conclusion that induction of a “totipotent” state to the somatic cell nuclei prior to haploidization has never been taken into consideration. The message our chapter conveys is that advancements in knowledge of in vitro somatic cell reprogramming, and remodeling of somatic cells injected into “selectively enucleated germinal vesicle” (SEGV) oocytes, make realistic the production of artificial gametes through haploidization of somatic cells by nuclear transfer.
Czech name
—
Czech description
—
Classification
Type
C - Chapter in a specialist book
CEP classification
—
OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
ISBN
978-11-0888-759-5
Number of pages of the result
6
Pages from-to
148-153
Number of pages of the book
196
Publisher name
Cambridge University Press
Place of publication
Cambridge
UT code for WoS chapter
—