New glutathione formulation for sustained release from gastrointestinal tract Asian Congress on Biotechnology (Poster. Asian Congress on Biotechnology 2013. December 15-19, 2013. Dilli, India).
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027022%3A_____%2F13%3A00000439" target="_blank" >RIV/00027022:_____/13:00000439 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
New glutathione formulation for sustained release from gastrointestinal tract Asian Congress on Biotechnology (Poster. Asian Congress on Biotechnology 2013. December 15-19, 2013. Dilli, India).
Original language description
To improve glutathione bioavailability after oral administration we have incorporated it into microparticles of ethylcellulose and/or cellulose acetate phthalate. Commercial FMC?s Aquacoat? EC (ethylcellulose) and Aquacoat? CPD (cellulose acetate phthalate) pseudo-latex preparations have been used for the microparticles production. FMC?s Aquacoat? pseudo-latex technology enables aqueous presentation of water-insoluble polymers. These reliable aqueous functional coatings are designed for use in both pharmaceutical and nutritional solid dose applications. They provide desired modified release profiles with the added benefit of global regulatory acceptance. Chitosan (medium molecular weight ) was added to the Aquacoat? pseudo-latex mixtures in amount of 5- 10 % of DM to improve mucoadhesivity of the microparticles. Two methods of the microparticles preparation were tested and compared ? conventional spray drying and the carbon dioxide assisted nebulisation.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/FR-TI3%2F496" target="_blank" >FR-TI3/496: Development of production technology and application forms of glutathione with high bioavailibility for the suppression of oxidative stress (radiation, chemotherapy)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů