2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000569" target="_blank" >RIV/00027162:_____/09:#0000569 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/09:00327032

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells

Original language description

In this study we analyzed the effects of 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB 153) on proteins involved in the formation of adherens junctions in WB-F344 cells. PCB 153 induced a gradual degradation of E-adherin, beta-catenin or plakoglobin proteins. PCB 153 had no effect on mRNA levels of the above mentioned proteins. PCB 153 also decreased levels of the active beta-catenin form, which is the key co-activator of Wnt-induced TCF/LEF-dependent gene expression and reduced Axin2 mRNA, a known Wnt signaling transcriptional target. Nevertheless, PCB 153 had no effect on phosphorylation of glycogen synthase kinase-3beta, which is supposed to target beta-catenin for its proteasomal degradation. Taken together, the present data suggest that PCB 153 may interfere with functions of adherens junction proteins involved in both cell-to-cell communication and intracellular signaling. Such mechanisms might be involved in the effects of non-dioxin-like PCBs contributing to liver tumor promotion.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

<a href="/en/project/GA524%2F06%2F0517" target="_blank" >GA524/06/0517: Mechanisms of disruption of cell-to-cell communication and regulation of cell proliferation in liver cells</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

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Volume of the periodical

260

Issue of the periodical within the volume

1-3

Country of publishing house

IE - IRELAND

Number of pages

8

Pages from-to

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UT code for WoS article

000267161000013

EID of the result in the Scopus database

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