Ectopic activation of Wnt/beta-catenin sgnaling in lens fiber cells results in cataract formation and aberrant fiber cell differentiation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00422571" target="_blank" >RIV/68378050:_____/13:00422571 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0078279" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0078279</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0078279" target="_blank" >10.1371/journal.pone.0078279</a>
Alternative languages
Result language
angličtina
Original language name
Ectopic activation of Wnt/beta-catenin sgnaling in lens fiber cells results in cataract formation and aberrant fiber cell differentiation
Original language description
The Wnt/beta-catenin signaling pathway controls many processes during development, including cell proliferation, cell differentiation and tissue homeostasis, and its aberrant regulation has been linked to various pathologies. In this study we investigated the effect of ectopic activation of Wnt/beta-catenin signaling during lens fiber cell differentiation. To activate Wnt/beta-catenin signaling in lens fiber cells, the transgenic mouse referred to as alpha A-CLEF was generated, in which the transactivation domain of beta-catenin was fused to the DNA-binding protein LEF1, and expression of the transgene was controlled by alpha A-crystallin promoter. Constitutive activation of Wnt/beta-catenin signaling in lens fiber cells of alpha A-CLEF mice resulted in abnormal and delayed fiber cell differentiation. Moreover, adult alpha A-CLEF mice developed cataract, microphthalmia and manifested downregulated levels of gamma-crystallins in lenses. We provide evidence of aberrant expression of cell
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
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UT code for WoS article
000326334500108
EID of the result in the Scopus database
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