Wnt/beta-Catenin Signaling Induces Integrin alpha 4 beta 1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00100351" target="_blank" >RIV/00216224:14740/17:00100351 - isvavai.cz</a>

Result on the web

<a href="http://www.jimmunol.org/content/199/9/3031" target="_blank" >http://www.jimmunol.org/content/199/9/3031</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4049/jimmunol.1700247" target="_blank" >10.4049/jimmunol.1700247</a>

Result language

angličtina

Original language name

Wnt/beta-Catenin Signaling Induces Integrin alpha 4 beta 1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice

Original language description

The mechanisms leading to autoimmune and inflammatory diseases in the CNS have not been elucidated. The environmental triggers of the aberrant presence of CD4(+) T cells in the CNS are not known. In this article, we report that abnormal beta-catenin expression in T cells drives a fatal neuroinflammatory disease in mice that is characterized by CNS infiltration of T cells, glial activation, and progressive loss of motor function. We show that enhanced beta-catenin expression in T cells leads to aberrant and Th1-biased T cell activation, enhanced expression of integrin alpha 4 beta 1, and infiltration of activated T cells into the spinal cord, without affecting regulatory T cell function. Importantly, expression of beta-catenin in mature naive T cells was sufficient to drive integrin alpha 4 beta 1 expression and CNS migration, whereas pharmacologic inhibition of integrin alpha 4 beta 1 reduced the abnormal T cell presence in the CNS of beta-catenin-expressing mice. Together, these results implicate deregulation of the Wnt/beta-catenin pathway in CNS inflammation and suggest novel therapeutic strategies for neuroinflammatory disorders.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of immunology

ISSN

0022-1767

e-ISSN

—

Volume of the periodical

199

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

3031-3041

UT code for WoS article

000413466400005

EID of the result in the Scopus database

2-s2.0-85032033490