SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000751" target="_blank" >RIV/00027162:_____/11:#0000751 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/1297-9716-42-16" target="_blank" >http://dx.doi.org/10.1186/1297-9716-42-16</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1297-9716-42-16" target="_blank" >10.1186/1297-9716-42-16</a>

Result language
angličtina
Original language name
SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression
Original language description
Genes localized at Salmonella pathogenicity island-1 (SPI-1) are involved in Salmonella invasion of host non-professional phagocytes. In addition to invasion, SPI-1-encoded proteins induce cell death of macrophages via activation of caspase-1 which alsocleaves proIL-1 beta and proIL-18, precursors of 2 proinflammatory cytokines. We were therefore interested in whether SPI-1-encoded type III secretion system (T3SS) may influence proinflammatory response of macrophages. We infected primary porcine alveolar macrophages with wild-type S. Typhimurium and S. Enteritidis and their SPI-1 deletion mutants. SPI1 mutants of both serovars invaded approx. 5 times less efficiently than the wild-type strains and despite this, macrophages responded to the infection with Delta SPI1 mutants by increased expression of proinflammatory cytokines. Our results showed that the SPI-1-encoded T3SS is required not only for cell invasion but in macrophages also for the suppression of early proinflammatory cytoki
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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