The cell adhesion and cytotoxicity effects of the derivate of vitamin E compared for two cell lines using a piezoelectric biosensor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F12%3A%230000929" target="_blank" >RIV/00027162:_____/12:#0000929 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/12:00080243
Result on the web
<a href="http://dx.doi.org/10.1016/j.snb.2012.08.047" target="_blank" >http://dx.doi.org/10.1016/j.snb.2012.08.047</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2012.08.047" target="_blank" >10.1016/j.snb.2012.08.047</a>
Alternative languages
Result language
angličtina
Original language name
The cell adhesion and cytotoxicity effects of the derivate of vitamin E compared for two cell lines using a piezoelectric biosensor
Original language description
The quartz crystal microbalance (QCM) was used to construct a piezoelectric biosensor utilizing rat liver epithelial cells (WB F344) and lung melanoma cells (B16F10) as biorecognition elements. The cells adhered on the gold surface modified by either hydrophobic polystyrene or fibronectin. The simultaneous monitoring of changes in the resonant frequency Delta f and the resistance Delta R corresponded with the mass and viscoelastic properties of the adhered cells. In addition, the bound cells were stained using fluorescent probes to evaluate their viability on the non-transparent gold surface. Furthermore, this piezoelectric biosensor was used for monitoring of drug-induced apoptosis initiated by micromolar concentrations of alpha-tocopherol amidomalate(alpha-TAM), a potential anticancer drug. The characteristic features of apoptosis as shrinkage and disintegration of cell-cell contacts could be monitored by QCM. The decrease of frequency and increase of resistance characterized gradua
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sensors and Actuators B-Chemical
ISSN
0925-4005
e-ISSN
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Volume of the periodical
174
Issue of the periodical within the volume
"Neuveden"
Country of publishing house
CH - SWITZERLAND
Number of pages
5
Pages from-to
153-157
UT code for WoS article
000311329000022
EID of the result in the Scopus database
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