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Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F14%3A%230001272" target="_blank" >RIV/00027162:_____/14:#0001272 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b" target="_blank" >http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2478/acph-2014-0032" target="_blank" >10.2478/acph-2014-0032</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

  • Original language description

    The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirring speed of a mechanical stirrer (600, 1000 rpm), emulsifier concentrations (PVA concentration 0.1 %, 1 %) and solvent selection (dichloromethane, ethyl acetate) on microparticle characteristics (encapsulation efficiency, drug loading, burst effect) were observed. It was found that with increased stirring speed, the PVA concentration or the use of ethyl acetate had a significantly negative effect on encapsulation efficiency. In addition, ethyl acetate had an adverse effect on the burst effect, while increased stirring speed had the opposite effect. Drug load was not affected by any particular variable, but rather by the interactions of evaluated variables

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Pharmaceutica

  • ISSN

    1330-0075

  • e-ISSN

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    HR - CROATIA

  • Number of pages

    15

  • Pages from-to

    403-417

  • UT code for WoS article

  • EID of the result in the Scopus database