Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872054" target="_blank" >RIV/62157124:16370/13:43872054 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release
Original language description
PLGA microparticles for sustained release of ibuprofen as the model drug were prepared by O/W solvent evaporation method under altering stirring speed (600, 1000 rpm), emulsifier concentration (PVA concentration 0.1%, 1%) and organic solvent selection (dichloromethane, ethyl acetate). Obtained results confirmed the effect of selected formulation and process parameters on properties of prepared PLGA-based microparticles. The influence on encapsulation efficiency, yield, morphological properties, mean size and drug release was observed. The increased stirring speed within the solvent evaporation process led to decrease of encapsulation efficiency, yield and mean size but incorporated drug was released faster. Increased PVA concentration in external emulsion phase brought same results except ibuprofen release rate. Microparticles prepared with dichloromethane as the organic solvent exhibit higher sphericity, more regular shape with smooth surface, thus dichloromethane was considered as mo
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Česká a slovenská farmacie
ISSN
1210-7816
e-ISSN
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Volume of the periodical
62
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
120-126
UT code for WoS article
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EID of the result in the Scopus database
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