The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873124" target="_blank" >RIV/62157124:16370/14:43873124 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/acph-2014-0032" target="_blank" >http://dx.doi.org/10.2478/acph-2014-0032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/acph-2014-0032" target="_blank" >10.2478/acph-2014-0032</a>
Alternative languages
Result language
angličtina
Original language name
The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis
Original language description
The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirring speed of a mechanical stirrer (600, 1000 rpm), emulsifier concentrations (PVA concentration 0.1 %, 1 %) and solvent selection (dichlormethane, ethyl acetate) on microparticles characteristics (encapsulation efficiency, drug loading, burst effect) were observed. It was found that with increased stirring speed, the PVA concentration or the use of ethyl acetate had a significantly negative effect on encapsulation efficiency. In addition, ethyl acetate had anadverse effect on the burst effect, while the increased stirring speed had the opposite effect. Drug load was not affected by any individual variable, but rather by the interactions of evaluated variables.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta pharmaceutica
ISSN
1330-0075
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
4
Country of publishing house
HR - CROATIA
Number of pages
15
Pages from-to
403-417
UT code for WoS article
000346704800002
EID of the result in the Scopus database
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