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DNA Vaccines for the Induction of Immune Responses in Mucosal Tisssues

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F15%3A%230001236" target="_blank" >RIV/00027162:_____/15:#0001236 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.15002-5" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-415847-4.15002-5</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.15002-5" target="_blank" >10.1016/B978-0-12-415847-4.15002-5</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    DNA Vaccines for the Induction of Immune Responses in Mucosal Tisssues

  • Original language description

    DNA vaccines represent an innovative approach allowing the induction of humoral and cell-mediated antigen-specific immune response in systemic and mucosal compartments. Vaccines consist of plasmid DNA-encoding antigens that become expressed in host cells, including species-specific posttranslational modifications. DNA vaccines elicit CD8 T cell responses in most experiments through cross-presentation of antigen. Because most pathogens invade hosts through mucosal surfaces, the induction of mucosal and systemic immunity is of paramount importance. Although systemic DNA vaccination exhibits high efficiency, generally weaker immune responses are induced by mucosal DNA administration. However, systemic immunization with selected viral and bacterial vaccines may also protect against mucosal infections. Furthermore, in contrast to high immunogenicity confirmed in small experimental animals, human DNA vaccines require further optimization to exhibit a protective effect. Therefore, various sys

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Mucosal Immunology

  • ISBN

    9780124158474

  • Number of pages of the result

    22

  • Pages from-to

    1307-1328

  • Number of pages of the book

    2564

  • Publisher name

    Elsevier

  • Place of publication

    Nizozemí

  • UT code for WoS chapter