DNA Vaccines for the Induction of Immune Responses in Mucosal Tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33157359" target="_blank" >RIV/61989592:15110/15:33157359 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00067-7" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-415847-4.00067-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00067-7" target="_blank" >10.1016/B978-0-12-415847-4.00067-7</a>
Alternative languages
Result language
angličtina
Original language name
DNA Vaccines for the Induction of Immune Responses in Mucosal Tissues
Original language description
DNA vaccines represent an innovative approach allowing the induction of humoral and cell-mediated antigen-specific immune response in systemic and mucosal compartments. Vaccines consist of plasmid DNA-encoding antigens that become expressed in host cells, including species-specific posttranslational modifications. DNA vaccines elicit CD8 T cell responses in most experiments through cross-presentation of antigen. Because most pathogens invade hosts through mucosal surfaces, the induction of mucosal and systemic immunity is of paramount importance. Although systemic DNA vaccination exhibits high efficiency, generally weaker immune responses are induced by mucosal DNA administration. However, systemic immunization with selected viral and bacterial vaccines may also protect against mucosal infections. Furthermore, in contrast to high immunogenicity confirmed in small experimental animals, human DNA vaccines require further optimization to exhibit a protective effect. Therefore, various sys
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Mucosal Immunology
ISBN
978-0-12-415847-4
Number of pages of the result
29
Pages from-to
"1307-1335"
Number of pages of the book
2564
Publisher name
Elsevier
Place of publication
Amsterdam
UT code for WoS chapter
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