Fatal tick-borne encephalitis in an immunosuppressed 12-year-old patient
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000053" target="_blank" >RIV/00027162:_____/16:N0000053 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/16:00468323
Result on the web
<a href="https://www.researchgate.net/publication/284655039_Fatal_tick-borne_encephalitis_in_an_immunosuppressed_12-year-old_patient" target="_blank" >https://www.researchgate.net/publication/284655039_Fatal_tick-borne_encephalitis_in_an_immunosuppressed_12-year-old_patient</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcv.2015.11.029" target="_blank" >10.1016/j.jcv.2015.11.029</a>
Alternative languages
Result language
angličtina
Original language name
Fatal tick-borne encephalitis in an immunosuppressed 12-year-old patient
Original language description
A 12-year-old Czech boy, previously healthy, without travel history, was admitted with 4 days of pyrexia, mild neck stiffness and otherwise normal physical examination. He had a recent tick bite and was not vaccinated against TBE. Initial blood tests showed mild leucopoenia and thrombocytopenia . TBE IgG and IgM (ELISA) were negative. Daily fever up to 39 °C persisted. Laboratory findings five days later revealed further decrease in leukocyte and platelet counts, along with anaemia. Sternal puncture done 7 days into admission was compatible with haemophagocytic lymphohistiocytosis. The patient was transferred to Haematology service to receive standard regimen of dexamethazone and etoposide. Fever resolved, blood parameters improved, however, 8 days later fever relapsed together with severe neck stiffness, tremor, and general weakness, rapidly progressing to quadriplegia, respiratory insufficiency, and coma. CSF study revealed raised protein and lymphocytes. TBE serology at this time was highly positive in both IgG and IgM. Other causes of brain infection/inflammation were ruled out. Despite complex intensive care the condition did not show any improvement and the patient died 31 weeks later.Immunosuppression probably contributed to virus replication in this patient. Bicytopenia is an established feature in the first phase of TBE. A prudent approach to commencing immunosuppression is warranted in the endemic area of TBE as TBE may mimic some of other haematological conditions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Virology
ISSN
1386-6532
e-ISSN
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Volume of the periodical
Neuveden
Issue of the periodical within the volume
74
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
2
Pages from-to
73-74
UT code for WoS article
000367391800016
EID of the result in the Scopus database
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