Colon Cancer and Perturbations of the Sphingolipid Metabolism

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000177" target="_blank" >RIV/00027162:_____/19:N0000177 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/19:00520477
Result on the web
<a href="https://www.mdpi.com/1422-0067/20/23/6051" target="_blank" >https://www.mdpi.com/1422-0067/20/23/6051</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms20236051" target="_blank" >10.3390/ijms20236051</a>

Result language
angličtina
Original language name
Colon Cancer and Perturbations of the Sphingolipid Metabolism
Original language description
Colon Cancer and Perturbations of theSphingolipid Metabolism - The development and progression of colorectal cancer (CRC), a major cause of cancer-relateddeath in the western world, is accompanied with alterations of sphingolipid (SL) composition in colontumors. A number of enzymes involved in the SL metabolism have been found to be deregulatedin human colon tumors, in experimental rodent studies, and in human colon cancer cellsin vitro.Therefore, the enzymatic pathways that modulate SL levels have received a significant attention, due to their possible contribution to CRC development, or as potential therapeutic targets. Many of theseenzymes are associated with an increased sphingosine-1-phosphate/ceramide ratio, which is in turnlinked with increased colon cancer cell survival, proliferation and cancer progression. Nevertheless,more attention should also be paid to the more complex SLs, including specific glycosphingolipids,such as lactosylceramides, which can be also deregulated during CRC development. In this review,we focus on the potential roles of individual SLs/SL metabolism enzymes in colon cancer, as wellas on the pros and cons of employing the current in vitro models of colon cancer cells for lipidomicstudies investigating the SL metabolism in CRC.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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