Sphingolipidomics of colon cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000106" target="_blank" >RIV/00027162:_____/23:N0000106 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Sphingolipidomics of colon cancer

Original language description

Oral presentation. In: Genetická toxikológia a prevencia rakoviny, Smolenice, Slovensko, 12.-15.6.2023, p. 13. Sphingolipids (SLs) and glycosphingolipids (GSLs) are important components of cell membranes and membrane microdomains; they also act as intracellular signaling molecules. Deregulation of tumor cell lipidome may thus contribute both to the alteration of lipid signaling and modulation of membrane properties in tumor cells. Major genetic changes linked to colorectal cancer (CRC) include mutations in APC, KRAS, TP53, and mismatch repair genes. Additionally, modifications of expression of protooncogenes (c-Fos, c-Jun, c-Myc) and related intracellular signal transduction pathways have been reported in CRC. However, the functional links among regulatory pathways and changes in SL/GSL metabolism remain poorly characterized. We are missing particular information about: 1. differences among SL/GSL levels and expression of genes/proteins related to SL/GSL metabolism in tumor cells vs. adjacent non-tumor tissues; 2. mechanisms regulating expression and activity of genes of SL/GSL metabolism both in normal colon tissue and during colon carcinogenesis; 3. roles(s) of related biosynthetic pathways, including de novo fatty acid synthesis in deregulation of SL/GSL levels; 4. potential functional roles of SLs and GSLs during colon cancer development. So far, only limited characterization of specific changes in lipid metabolites and genes/proteins has been reported. The molecular basis of regulation of SL/GSL metabolism is largely unknown, although several studies suggested possible roles of transcription factors related to epithelial-mesenchymal transition in alterations of gene expression and chaperone proteins in induction of enzymatic activities. Upregulation of fatty acid synthesis in CRC and/or glucose metabolism might be also interconnected with induced SL and GSL biosynthesis. Taken together, specific patterns of SL/GSL levels could be linked with carcinogenesis, and newly identified metabolites and genes could become promising CRC biomarkers and/or potential therapeutic targets. The proposed lecture is intended to summarize recent advances in (sphingo)lipidomics and related SL/GSL metabolic gene expression studies in CRC and colon cancer cells.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30108 - Toxicology

Project

<a href="/en/project/NU21-03-00421" target="_blank" >NU21-03-00421: Glycosphingolipids and their metabolic pathways as potential colon cancer biomarkers</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů