Ni and TiO2 nanoparticles cause adhesion and cytoskeletal changes in human osteoblasts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000018" target="_blank" >RIV/00027162:_____/21:N0000018 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00120075
Result on the web
<a href="https://link.springer.com/article/10.1007/s11356-020-10908-8" target="_blank" >https://link.springer.com/article/10.1007/s11356-020-10908-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11356-020-10908-8" target="_blank" >10.1007/s11356-020-10908-8</a>
Alternative languages
Result language
angličtina
Original language name
Ni and TiO2 nanoparticles cause adhesion and cytoskeletal changes in human osteoblasts
Original language description
Titanium-based alloys have established a crucial role in implantology. As material deteriorates overtime, nanoparticles of TiO2 and Ni are released. This study is focused on the impact of TiO2 and Ni nanoparticles with size of 100 nm on cytoskeletal and adhesive changes in human physiological and osteoarthritic osteoblasts. The impact of nanoparticles with concentration of 1.5 ng/mL on actin and tubulin expression and gene expression of FAK and ICAM-1 was studied. The cell size and actin expression of physiological osteoblasts decreased in presence of Ni nanoparticles, while TiO2 nanoparticles caused increase in cell size and actin expression. Both cell lines expressed more FAK as a response to TiO2 nanoparticles. ICAM-1 gene was overexpressed in both cell lines as a reaction to both types of nanoparticles. The presented study shows a crucial role of Ni and TiO2 nanoparticles in human osteoblast cytoskeletal and adhesive changes, especially connected with the osteoarthritic cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Pollution Research
ISSN
0944-1344
e-ISSN
1614-7499
Volume of the periodical
28
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
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UT code for WoS article
000572893700002
EID of the result in the Scopus database
2-s2.0-85091480222