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Raw bovine milk as a reservoir of yeast with virulence factors and decreased susceptibility to antifungal agents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000168" target="_blank" >RIV/00027162:_____/21:N0000168 - isvavai.cz</a>

  • Result on the web

    <a href="https://academic.oup.com/mmy/article-abstract/59/10/1032/6309310?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/mmy/article-abstract/59/10/1032/6309310?redirectedFrom=fulltext</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/mmy/myab036" target="_blank" >10.1093/mmy/myab036</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Raw bovine milk as a reservoir of yeast with virulence factors and decreased susceptibility to antifungal agents

  • Original language description

    In recent years, increased rates of yeast infections in humans and animals are recognized worldwide. Considering that animals can represent a source of yeast infections for humans, knowing the antifungal susceptibility profile of yeast isolates from milk and evaluating their pathogenic potential would be of great medical importance. Therefore, the aim of this survey was to study yeast diversity in milk samples, determine hemolytic and phospholipase activities of isolates and establish minimal inhibition concentration (MIC) for fluconazole, voriconazole and flucytosine, using microdilution method. Out of 66 yeast isolates from raw milk samples of 910 subclinically infected cows, 26 different yeast species were determined based on sequencing of the D1/D2 region and ITS region. Among them, Pichia kudriavzevii (9; Candida krusei), Kluyveromyces marxianus (8; Candida kefyr) and Debaryomyces hansenii (8; Candida famata) were the most commonly identified. Hemolysin and phospholipase activity was observed in more than half percent of isolates, separately. The elevated MIC for fluconazole above 4 mg/ml was determined in 16 isolates of 11 species except for intrinsically resistant isolates of P. kudriavzevii. The findings of this study demonstrate that yeast isolates from raw milk have the potential to express virulence attributes such as hemolysin and phospholipase and additionally, some of these strains showed elevated MIC to fluconazole or to flucytosin.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    40200 - Animal and Dairy science

Result continuities

  • Project

    <a href="/en/project/QK1910092" target="_blank" >QK1910092: Non-bacterial agents of mastitis and their influence on the quality and technological properties of milk</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Medical Mycology

  • ISSN

    1369-3786

  • e-ISSN

    1460-2709

  • Volume of the periodical

    59

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    1032–1040

  • UT code for WoS article

    000709571800011

  • EID of the result in the Scopus database

    2-s2.0-85117388473