Development vaccine against Streptococcus suis infection in pig

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000131" target="_blank" >RIV/00027162:_____/22:N0000131 - isvavai.cz</a>

Result on the web

<a href="https://www.hostpathogen.com/program-speakers" target="_blank" >https://www.hostpathogen.com/program-speakers</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Development vaccine against Streptococcus suis infection in pig

Original language description

Development of vaccines against streptococcal infection is challenging due to nature of the interaction between the pathogen and the host immune system. In last decades, vaccines based on conjugates of capsular polysaccharide and carrier protein were proved to be protective against various bacterial pathogens, including streptococcal infections in humans. However, the manufacturing cost is limiting for their use in animals. Although Streptococcus suis infection in pig is currently considered to be one of most important bacterial disease, an effective commercial vaccine is still not available. We thus tested an experimental vaccine against Streptococcus suis serotype 2 based on capsular polysaccharide conjugated to chicken ovalbumin and compared its immunogenicity and protectivity with a vaccine based on CRM197 conjugate. Ovalbumin was selected as a cheap alternative to recombinant carrier proteins widely used in vaccines for human use. We found that the ovalbumin-based experimental vaccine successfully induced immune response in pigs, and the IgG antibody response was even higher than after immunization with capsular polysaccharide CRM197 conjugate. Protectivity of vaccination against infection was evaluated in the challenge experiment and was found promising for both conjugates. This work was supported by Ministry of Agriculture of the Czech Republic (Institutional Support No.MZE-RO0518) and by the National Agency for Agricultural Research (Project No. QK1810193).

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

<a href="/en/project/QK1810193" target="_blank" >QK1810193: Modern methods of diagnosis, therapy and prevention of Streptococcus suis infections as a tool for designing of targeted control programs in pig herds</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů