Vaccine against Streptococcus suis Infection in Pig Based on Alternative Carrier Protein Conjugate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000132" target="_blank" >RIV/00027162:_____/22:N0000132 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/22:43922327 RIV/00216224:14310/22:00128096 RIV/61988987:17110/22:A2302H1T
Result on the web
<a href="https://www.mdpi.com/2076-393X/10/10/1620" target="_blank" >https://www.mdpi.com/2076-393X/10/10/1620</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/vaccines10101620" target="_blank" >10.3390/vaccines10101620</a>
Alternative languages
Result language
angličtina
Original language name
Vaccine against Streptococcus suis Infection in Pig Based on Alternative Carrier Protein Conjugate
Original language description
Streptococcus suis is a serious pathogen in the pig industry with zoonotic potential. With respect to the current effort to reduce antibiotic use in animals, a prophylactic measure is needed to control the disease burden. Unfortunately, immunization against streptococcal pathogens is challenging due to nature of the interaction between the pathogen and the host immune system, but vaccines based on conjugates of capsular polysaccharide (CPS) and carrier protein were proved to be efficient. The main obstacle of these vaccines is manufacturing cost, limiting their use in animals. In this work, we tested an experimental vaccine against Streptococcus suis serotype 2 based on capsular polysaccharide conjugated to chicken ovalbumin (OVA) and compared its immunogenicity and protectivity with a vaccine based on CRM197 conjugate. Ovalbumin was selected as a cheap alternative to recombinant carrier proteins widely used in vaccines for human use. We found that the ovalbumin-based experimental vaccine successfully induced immune response in pigs, and the IgG antibody response was even higher than after immunization with capsular polysaccharide CRM197 conjugate. Protectivity of vaccination against infection was evaluated in the challenge experiment and was found promising for both conjugates.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
<a href="/en/project/QK1810193" target="_blank" >QK1810193: Modern methods of diagnosis, therapy and prevention of Streptococcus suis infections as a tool for designing of targeted control programs in pig herds</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vaccines
ISSN
2076-393X
e-ISSN
2076-393X
Volume of the periodical
10
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
"1620"
UT code for WoS article
000873669400001
EID of the result in the Scopus database
2-s2.0-85140801371