APC/C activity during transition from meiosis into mitosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000224" target="_blank" >RIV/00027162:_____/23:N0000224 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
APC/C activity during transition from meiosis into mitosis
Original language description
Early development in mammals is characterized by dramatic events, such as two consecutive meiotic divisions, fertilization and early cleavage cycles of blastomeres in the newly formed embryo. Moreover, during meiosis and the first embryonic cleavage cycles, cells remain transcriptionally silent, which renders regulated translation, posttranslational modifications and proteolysis essential for controlling cell cycle and chromosome segregation. During this period, oocytes, as well as blastomeres of early embryos, frequently suffer from aneuploidy. In fact, aneuploidy is the leading cause of failure of early development in mammals, including human. It is therefore vital to obtain better understanding of the cell cycle regulatory mechanisms during this period. In our study, we focused on the maintenance of essential cell cycle regulatory proteins, such as cyclins and securin, during transition from meiosis into mitosis, when the cells are transcriptionally silent.
Czech name
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Czech description
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Project
<a href="/en/project/GA20-25850S" target="_blank" >GA20-25850S: Control of anaphase entry during early development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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