Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00584104" target="_blank" >RIV/67985904:_____/24:00584104 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/24:00135722 RIV/00027162:_____/24:N0000014

Result on the web

<a href="https://www.mdpi.com/1422-0067/25/4/2101" target="_blank" >https://www.mdpi.com/1422-0067/25/4/2101</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms25042101" target="_blank" >10.3390/ijms25042101</a>

Result language

angličtina

Original language name

Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?

Original language description

Chromosome segregation in female germ cells and early embryonic blastomeres is known to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of termination of early development and embryo loss in mammals. And in specific cases, when the aneuploidy is actually compatible with embryonic and fetal development, it leads to severe developmental disorders. The main surveillance mechanism, which is essential for the fidelity of chromosome segregation, is the Spindle Assembly Checkpoint (SAC). And although all eukaryotic cells carry genes required for SAC, it is not clear whether this pathway is active in all cell types, including blastomeres of early embryos. In this review, we will summarize and discuss the recent progress in our understanding of the mechanisms controlling chromosome segregation and how they might work in embryos and mammalian embryos in particular. Our conclusion from the current literature is that the early mammalian embryos show limited capabilities to react to chromosome segregation defects, which might, at least partially, explain the widespread problem of aneuploidy during the early development in mammals.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/GA19-24528S" target="_blank" >GA19-24528S: The relationship between cell size and the size of cellular organelles during early embryonic development in mammals</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

1422-0067

Volume of the periodical

25

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

2101

UT code for WoS article

001172049100001

EID of the result in the Scopus database

2-s2.0-85185954676