Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F11%3A9827" target="_blank" >RIV/00064165:_____/11:9827 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/11:00372287 RIV/60461373:22340/11:43892283 RIV/00216208:11110/11:9827

Result on the web

<a href="http://dx.doi.org/10.1016/j.bmcl.2011.06.101" target="_blank" >http://dx.doi.org/10.1016/j.bmcl.2011.06.101</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

Original language description

We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery systemfor cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targetingproteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system. (C) 2011 Elsevier Ltd. All rights reserved.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic & Medicinal Chemistry Letters

ISSN

0960-894X

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

18

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

5514-5520

UT code for WoS article

000294051800080

EID of the result in the Scopus database

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