Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00603449" target="_blank" >RIV/61389013:_____/25:00603449 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/17425247.2024.2436081" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/17425247.2024.2436081</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?
Original language description
Biocompatible copolymer-based nanoparticles are gaining attention as anticancer drug delivery carriers due to their ease of production, ability to improve drug solubility, and targeted release properties. Stimuli-responsive hybrid copolymer nanoparticles, particularly those responsive to pH and reactive oxygen species (ROS), are promising for enhancing specificity in drug delivery. Examples include arylboronate ester-protected polymer amines and ferrocenylbased copolymers, which release their cargo upon ROS-triggered transformation. Coordination polymers (CPs) offer unique benefits due to their metal-organic composition, including biodegradability and potential therapeutic activity. CP-based nanoparticles, combined with radionuclides, show promise in theranostic applications, especially in delivering Auger electron emitters for targeted radiation therapy. Furthermore, ROS-responsive nanoparticles could be valuable in drug-free therapeutics, sensors, and anticancer vaccines, with their ability to interact selectively with cancerous or inflamed tissues.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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