Dual thermo- and ROS-responsive triblock copolymers as 19F MRI tracers for functional nanoparticles and hydrogels

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00638465" target="_blank" >RIV/61389013:_____/25:00638465 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/25:00638465 RIV/00216208:11110/25:10501933

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0014305725004999?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305725004999?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2025.114211" target="_blank" >10.1016/j.eurpolymj.2025.114211</a>

Result language

angličtina

Original language name

Dual thermo- and ROS-responsive triblock copolymers as 19F MRI tracers for functional nanoparticles and hydrogels

Original language description

Theranostic systems that integrate therapeutic delivery with diagnostic imaging hold strong potential in biomedical applications. Nanocarriers with imaging and controlled release functions enable real-time tracking and localization of therapeutics, while hydrogels with diagnostic capabilities support applications such as sustained drug release, cell encapsulation, and cell tracking. Fluorine-19 magnetic resonance imaging (19F-MRI) is a promising non-invasive complement to conventional proton MRI, though its clinical translation remains limited by the lack of optimal tracer systems. Herein, we report the development of BAB-type triblock copolymers comprising a hydrophilic poly(2-ethyl-2-oxazoline) (PEtOx) A block and a thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA) B block, statistically copolymerized with a ROS-responsive monomer bearing phenylboronic ester groups. These polymers self-assemble into nanoparticles at low concentrations and form thermogelling hydrogels at higher concentrations, allowing for formulation-dependent versatility. The ROS-sensitive component enables disassembly at pathophysiologically relevant ROS levels (∼0.4–2 mM), facilitating targeted therapeutic release in oxidative environments such as tumors. The polymers form physically crosslinked nanogels (hydrodynamic radius ≈160–760 nm) at 37 °C, which undergo ROS-triggered disassembly. Selected formulations demonstrated excellent 19F-MRI relaxation properties suitable for in vivo imaging. Cytocompatibility was confirmed in vitro using human foreskin fibroblasts. Overall, the developed polymers offer a versatile platform for biomedical applications—ranging from thermogelling injectable hydrogels for drug delivery or cell encapsulation, to nanocarriers for ROS-triggered therapeutic release—all while enabling non-invasive monitoring via 19F-MRI.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Polymer Journal

ISSN

0014-3057

e-ISSN

1873-1945

Volume of the periodical

238

Issue of the periodical within the volume

24 September

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

114211

UT code for WoS article

001688206000001

EID of the result in the Scopus database

2-s2.0-105013252123