EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: A prospective observational cohort study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F12%3A12540" target="_blank" >RIV/00064165:_____/12:12540 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/12:00056335 RIV/00216208:11110/12:12540
Result on the web
<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.02.014" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2012.02.014</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: A prospective observational cohort study
Original language description
Objectives: EN-RAGE is extracellular newly identified receptor for advanced glycation end-products binding protein playing a role in inflammation. The aim was to test the relationship of EN-RAGE to prognosis of long-term hemodialysis patients (HD). Design and methods: This is a prospective observational cohort study in 261 HD patients followed up for five years. Laboratory parameters were measured at the beginning of the study. Results: EN-RAGE was slightly but unsignificantly increased in HD patients compared with healthy controls and correlated significantly with inflammatory markers. Univariate Cox analysis demonstrated ENRAGE as a significant predictor for mortality due to infection (HR (95%CI): 1.305 (1.063-1.602), per standard deviation, p = 0.01), but this significance disappeared in multivariate Cox analysis when CRP was included into the model. Conclusions: Our study demonstrates EN-RAGE as an inflammatory biomarker. It is related to mortality of HD patients due to infection,
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/NS10043" target="_blank" >NS10043: Genetic predisposition and new biochemical markers of cardiovascular risk in patients with chronic kidney diseases.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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