28 day post-operative persisted hypercoagulability after surgery for benign diseases: a prospective cohort study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10323319" target="_blank" >RIV/00064165:_____/16:10323319 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10323319 RIV/00216208:11510/16:10323319

Result on the web

<a href="http://dx.doi.org/10.1186/s12893-016-0128-3" target="_blank" >http://dx.doi.org/10.1186/s12893-016-0128-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12893-016-0128-3" target="_blank" >10.1186/s12893-016-0128-3</a>

Result language

angličtina

Original language name

28 day post-operative persisted hypercoagulability after surgery for benign diseases: a prospective cohort study

Original language description

Background: Surgery for benign disease is associated with a low-risk of developing venous thromboembolism (VTE). Despite a relatively low incidence of postoperative VTE in patients after elective cholecystectomy and abdominal hernia repair there are data proving hypercoagulability in the early postoperative period. We focused on assessment of the systemic inflammatory response and coagulation status in these surgical patients after hospital discharge. Methods: Prospectively, patients who underwent surgery for benign disease were included. Two hundred sixteen patients were enrolled - 90 patients in laparoscopic cholecystectomy (LC) group and 126 patients in hernia surgery (HS) group. Risk assessment of VTE according to the Caprini risk assessment model was performed in all patients. Prevalence of VTE in postoperative period was observed. Markers of systemic inflammatory response (IL-6, CRP, α-1-acid glycoprotein, transferrin) and coagulation markers (PLT, fibrinogen, prothrombin fragment F1 + 2 and D-dimer) were measured before surgery, on 7-10th postoperative day and on 28-30th postoperative day. Conclusions: Activated systemic inflammatory response and hypercoagulable condition were verified in patients after laparoscopic cholecystectomy and hernia surgery after their hospital discharge. Hypercoagulability persisted even a month after surgery. Nevertheless, we observed very low prevalence of clinically apparent VTE in patients with in-hospital postoperative VTE prophylaxis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

<a href="/en/project/NT13251" target="_blank" >NT13251: The influence of thrombophilic factors to the risk of postoperative venous thromboembolism (VTE) in patients indicated for elective surgery for cancer in the abdominal cavity.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Surgery

ISSN

1471-2482

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

000373322300001

EID of the result in the Scopus database

2-s2.0-84964414543