Coagulation profile after esophagectomy in SIRS and sepsis evaluated by thromboelastography and relationship with organ dysfunction development

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10324782" target="_blank" >RIV/00064203:_____/16:10324782 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10324782 RIV/00216208:11130/16:10324782

Result on the web

<a href="http://dx.doi.org/10.4149/BLL_2016_062" target="_blank" >http://dx.doi.org/10.4149/BLL_2016_062</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2016_062" target="_blank" >10.4149/BLL_2016_062</a>

Result language

angličtina

Original language name

Coagulation profile after esophagectomy in SIRS and sepsis evaluated by thromboelastography and relationship with organ dysfunction development

Original language description

OBJECTIVES: Assessment of organ dysfunction development and relationship to coagulation changes measured by standard coagulation tests and thromboelastography in patients after major surgery. BACKGROUND: Some authors reported that hypercoagulation present in systemic inflammatory response syndrome (SIRS) is caused by infection, while others reported hypocoagulation. We hypothesize that hemocoagulation status depends on severity and time course of sepsis/SIRS and that coagulation profile influences organ dysfunction. METHODS: Hemocoagulation profile was evaluated in patients undergoing surgical esophagectomy on the morning of surgery and then at 24-hour intervals for the following six days. Results: From 34 analyzed patients, 26 went through postoperative SIRS and eight patients developed sepsis complication. Hypercoagulation trend was found in both nonseptic and septic patients early after operation represented by short R and K. We also found significant correlation (p < 0.05) between antithrombin level and organ dysfunction score in both groups, for nonseptic group (r = 0.78, r(2) = 0.60) and for septic group (r = 0.94, r(2) = 0.88). CONCLUSION: Hemocoagulation in both SIRS and sepsis is initially accompanied by a hypercoagulation trend and low level of antithrombin is connected to organ dysfunction development. Therefore, normal antithrombin level might prevent organ dysfunction in postoperative period (Fig. 1, Ref. 14).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

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Volume of the periodical

117

Issue of the periodical within the volume

6

Country of publishing house

SK - SLOVAKIA

Number of pages

4

Pages from-to

312-315

UT code for WoS article

000378300700003

EID of the result in the Scopus database

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