Neurological manifestations in Wilson's disease -possible treatment options for symptoms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10326671" target="_blank" >RIV/00064165:_____/16:10326671 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10326671

Result on the web

<a href="http://dx.doi.org/10.1080/21678707.2016.1188003" target="_blank" >http://dx.doi.org/10.1080/21678707.2016.1188003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/21678707.2016.1188003" target="_blank" >10.1080/21678707.2016.1188003</a>

Result language

angličtina

Original language name

Neurological manifestations in Wilson's disease -possible treatment options for symptoms

Original language description

Introduction: Wilson's disease (WD) is a neurodegenerative disorder that presents mainly with liver symptoms, but may be accompanied by various neurological manifestations. WD can be successfully treated with chelators or zinc salts to correct the abnormal copper metabolism, which usually improves both liver function and the neurological deficits; however, improvement in neurological deficits can take years. Patients may initially present with severe neurological deficits that affect activities of daily living. Consequently, therapy to alleviate the neurological symptoms is needed. Treatment choices are often based on experience with other disorders with symptoms clinically similar to WD. Areas covered: Apart from general recommendations on the anti-copper therapy and liver transplantation in patients with WD, no guidelines for managing the neurological symptoms exist. Based on mainly case reports, this review describes the most frequent neurological symptoms and their possible treatments. Expert opinion: There is no strong evidence regarding treatment of neurological disturbances in patients with WD. Several case studies indicate that drugs used to treat movement disorders such as tremor, parkinsonism, or dystonia may also alleviate these symptoms in patients with WD. In the case of severe, disabling, neurological symptoms, the treatment options for symptoms should always be discussed with the patient.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NV15-25602A" target="_blank" >NV15-25602A: Biomarkers of progression and treatment response in neurodegenerative disorders</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Expert Opinion on Orphan Drugs

ISSN

2167-8707

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

719-728

UT code for WoS article

000382173000006

EID of the result in the Scopus database

2-s2.0-84975119902