Symptomatic treatment of neurologic symptoms in Wilson disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364541" target="_blank" >RIV/00216208:11110/17:10364541 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10364541

Result on the web

<a href="http://dx.doi.org/10.1016/B978-0-444-63625-6.00018-5" target="_blank" >http://dx.doi.org/10.1016/B978-0-444-63625-6.00018-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-444-63625-6.00018-5" target="_blank" >10.1016/B978-0-444-63625-6.00018-5</a>

Result language

angličtina

Original language name

Symptomatic treatment of neurologic symptoms in Wilson disease

Original language description

Wilson disease (WD) is a potentially treatable neurodegenerative disorder. In the majority of cases, treatment with drugs that induce a negative copper balance (usually chelators or zinc salts) leads to improvements in liver function and neurologic signs. However, some patients show severe neurologic symptoms at diagnosis, such as tremor, dystonia, parkinsonism, and chorea. In this patient group, some neurologic deficits may persist despite adequate treatment, and further neurologic deterioration may be observed after treatment initiation. Such patients may require additional treatment to alleviate neurologic symptoms. Apart from general recommendations for WD anticopper treatment, there are currently no guidelines for managing neurologic symptoms in WD. The aim of this chapter is to summarize possible treatments of neurologic symptoms in WD based on the presently available medical literature.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV15-25602A" target="_blank" >NV15-25602A: Biomarkers of progression and treatment response in neurodegenerative disorders</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Wilson disease

ISBN

978-0-444-63625-6

Number of pages of the result

13

Pages from-to

211-223

Number of pages of the book

264

Publisher name

Elsevier Science

Place of publication

Amsterdam

UT code for WoS chapter

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