Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10385725" target="_blank" >RIV/00064165:_____/19:10385725 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10385725

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bX~eMYrH-w" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bX~eMYrH-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1871527318666181224130011" target="_blank" >10.2174/1871527318666181224130011</a>

Result language

angličtina

Original language name

Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder

Original language description

We measured selected mitochondrial parameters in peripheral blood components. The analyses were performed for patients suffering from a manic episode and during remission and were compared to those performed for healthy controls. Mitochondrial respiration was examined in intact and permeabilized blood platelets using high-resolution respirometry. The citrate synthase (CS) and electron transport system (ETS) complex (complex I, II, and IV) activities were examined in platelets. The CS, complex II and complex IV activities were decreased in the BAD patients, complex I activity was increased, and the ratio of complex I to CS was significantly increased. In the intact platelets, respiration after complex I inhibition and residual oxygen consumption were decreased in the BAD patients compared to the healthy controls. In the permeabilized platelets, a decreased ETS capacity was found in the BAD patients. No significant differences were found between BAD patients in mania and remission. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities. We conclude that complex I and its abnormal activity contribute to defects in cellular energy metabolism during a manic episode and that the deficiency in the complex&apos;s functioning, but not the availability of oxidative phosphorylation substrates, seems to be responsible for the decreased ETS capacity in BAD patients. The observed parameters can be further evaluated as &apos;trait&apos; markers of BAD

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/NV15-28616A" target="_blank" >NV15-28616A: Mitochondrial dysfunctions in bipolar affective disorder</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CNS &amp; Neurological Disorders - Drug Targets

ISSN

1871-5273

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

222-231

UT code for WoS article

000466102200005

EID of the result in the Scopus database

2-s2.0-85065585115