Mitochondrial respiration in patients with bipolar disorder: Can mitochondrial respiratory control ratios serve as state and/or trait markers?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10501166" target="_blank" >RIV/00216208:11110/25:10501166 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/25:10501166

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=VbU8iM__oK" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=VbU8iM__oK</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jad.2025.119948" target="_blank" >10.1016/j.jad.2025.119948</a>

Result language

angličtina

Original language name

Mitochondrial respiration in patients with bipolar disorder: Can mitochondrial respiratory control ratios serve as state and/or trait markers?

Original language description

Background: Bipolar disorder (BD) is a multifactorial disorder whose pathophysiology is not fully understood. Mitochondrial dysfunction has been proposed as a part of the molecular background of BD. Mitochondrial dysfunction, manifested as changes in oxygen consumption, can be detected in peripheral blood and may serve as potential state or trait marker of BD. Methods: Mitochondrial respiration was analyzed in blood platelets obtained from BD patients in manic/ depressive episode and in remission and compared with controls. 52 BD patients and 66 healthy age-matched controls were recruited. BD was clinically assessed using diagnostic scales and questionnaires. High-resolution respirometry was used to determine mitochondrial respiratory control ratios in both intact and permeabilized platelets. Results: In BD patients in remission, the capacity of complex II-linked respiration and reserve respiration were decreased compared to controls in intact platelets. In permeabilized platelets, physiological respiration, electron transfer system (ETS) capacity, and excess capacity were decreased in BD patients compared to controls. When comparing acute states and remissions, more pronounced changes in respiratory parameters were observed in intact platelets after treatment of depression than after treatment of mania. In permeabilized platelets, qualitative changes in respiratory parameters did not depend on the type of episode prior to pharmacotherapy. Conclusions: Mitochondrial dysfunction is implicated in BD pathophysiology and is associated with alterations in both activity of respiratory complexes and availability of substrates for oxidative phosphorylation. In intact platelets, complex II-linked respiration/ETS capacity could be potential blood-based trait biomarker for BD. Complex I-linked respiration/ETS capacity in permeabilized platelets could serve as state marker.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/NU23-04-00032" target="_blank" >NU23-04-00032: Mitochondrial toxicity of tau protein oligomers and its regulation by drugs for Alzheimer's disease</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Affective Disorders

ISSN

0165-0327

e-ISSN

1573-2517

Volume of the periodical

391

Issue of the periodical within the volume

December

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

119948

UT code for WoS article

001550410100003

EID of the result in the Scopus database

2-s2.0-105011262528