Treatment of Wilson's disease - an update
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395744" target="_blank" >RIV/00064165:_____/19:10395744 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10395744
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D7h5twJV1D" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D7h5twJV1D</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/21678707.2019.1638248" target="_blank" >10.1080/21678707.2019.1638248</a>
Alternative languages
Result language
angličtina
Original language name
Treatment of Wilson's disease - an update
Original language description
Introduction: Wilson's disease (WD) is one of the few genetic disorders that can be successfully treated if diagnosed early and treated correctly. Currently, two groups of drugs are used in WD treatment: chelators or zinc salts. Both treatments lead to negative copper body balance, reversing the pathological accumulation of copper in tissues, and removing excess copper from the body. Liver transplantation is established as a treatment option in the case of acute liver failure or progressive liver disease resistant to treatment. However, due to the large number of adverse drug reactions, the need for long-life treatment and the persistence of symptoms, there is a need for new, more effective and safer therapies to alleviate WD symptoms. Areas covered: This article discusses available treatment recommendations (anticopper and liver transplantation) and reviews the possibilities of symptomatic WD treatment as well as available research regarding future WD treatments. Expert opinion: Existing recommendations concerning WD treatment as well as liver transplantation are consistent and up-to-date, irrespective of the progress made in the search for new treatment modalities. Additionally, several case reports, series reports, and reviews encourage the symptomatic treatment of WD clinical symptoms, taking into account their severity and impact on quality of life.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Expert Opinion on Orphan Drugs
ISSN
2167-8707
e-ISSN
—
Volume of the periodical
7
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
287-294
UT code for WoS article
000473988200001
EID of the result in the Scopus database
2-s2.0-85069535424