NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399964" target="_blank" >RIV/00064165:_____/19:10399964 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/19:00507580 RIV/60460709:41210/19:80969 RIV/00216208:11110/19:10399964 RIV/00216208:11310/19:10399964
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LKs-7LHr5i" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LKs-7LHr5i</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nano9060888" target="_blank" >10.3390/nano9060888</a>
Alternative languages
Result language
angličtina
Original language name
NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans
Original language description
The present pilot study tested the efficiency of nanoTiO(2) sunscreen to prevent the oxidative stress/inflammation caused by ultraviolet (UV) radiation using biomarkers in subjects' blood, urine, and exhaled breath condensate (EBC). In addition, the skin absorption of nanoTiO(2) was studied. Six identical subjects participated in three tests: (A) nanoTiO(2) sunscreen, (B) UV radiation, and (C) sunscreen + UV. The first samples were collected before the test and the second after sunscreen application and/or UV exposure. On day 4, the third samples were collected, and the sunscreen was washed off, and the fourth samples were collected on day 11. The following biomarkers were measured: malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, aldehydes C6-C12, 8-iso-Prostaglandin F2 alpha, o-tyrosine, 3-chlorotyrosine, 3-nitrotyrosine, 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine, 5-hydroxymethyl uracil, and leukotrienes, using liquid chromatography-electrospray ionisation-tandem mass spectrometry. Titania was measured using inductively coupled plasma mass spectrometry and TiO2 nanoparticles by transmission and scanning electron microscopy. Sunscreen alone did not elevate the markers, but UV increased the biomarkers in the plasma, urine, and EBC. The sunscreen prevented skin redness, however it did not inhibit the elevation of oxidative stress/inflammatory markers. Titania and nanoTiO(2) particles were found in the plasma and urine (but not in the EBC) in all sunscreen users, suggesting their skin absorption.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/GA18-02079S" target="_blank" >GA18-02079S: The effect of nanoparticles exposure on DNA alterations in a human population</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomaterials
ISSN
2079-4991
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
23
Pages from-to
888
UT code for WoS article
000475352900082
EID of the result in the Scopus database
2-s2.0-85070237976