Clinical and Prognostic Implications of Electrocardiography and Holter Monitoring Findings in Patients with Light Chain Cardiac Amyloidosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10498229" target="_blank" >RIV/00064165:_____/25:10498229 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10498229

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XA4jWa3YNX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XA4jWa3YNX</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s44411-024-00013-4" target="_blank" >10.1007/s44411-024-00013-4</a>

Result language

angličtina

Original language name

Clinical and Prognostic Implications of Electrocardiography and Holter Monitoring Findings in Patients with Light Chain Cardiac Amyloidosis

Original language description

Background: Cardiac involvement in light chain amyloidosis (AL-CA) represents an infiltrative heart disease. The aim of the study was to recognize differences between patients suffering from light chain amyloidosis with and without cardiac involvement in 12-lead electrocardiography (ECG) and 24-h Holter ECG monitoring. Methods: We prospectively analyzed data in 39 (median 66 [IQR 62;71] years, 62% males) consecutive patients with AL amyloidosis. Results: Out of all patients, AL-CA was confirmed in 26 (67%) subjects. All patients with AL-CA manifested at least one pathology ECG, which contrasted with a low prevalence of abnormal ECG findings in patients without cardiac involvement (54%), p &lt; 0.001. Abnormal Holter ECG findings were documented in 77% and 62% of patients with and without AL-CA. During 19 (7;59) months of follow-up, 19 (73%) patients with AL-CA died. The mortality rate was significantly lower in patients with QRS &lt; 100 ms and QTc &lt; 450 ms (both p &lt; 0.05). The absence of any pathology on 12-lead ECG had a negative predictive value of 100% for the presence of AL-CA. Conclusion: Standard 12-lead ECG seems to be a method with a relevant negative predictive value for the exclusion of AL-CA. The duration of QRS as well as QTc intervals seem to be a marker of early mortality.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy / Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

1336-0345

Volume of the periodical

126

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

202-210

UT code for WoS article

001465540600014

EID of the result in the Scopus database

2-s2.0-85217688089