Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F10%3A%230000049" target="_blank" >RIV/00064173:_____/10:#0000049 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.

Original language description

It is well know that oligomeric/aggregated amyloid B peptides are a key player in the pathogenesis of Alzheimer´sdisease and that different nanoparticles influance oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in the case ofprotein lysozyme, however, they have yet to be supported by biological samples containing peptides/proteins preaggregatedin vivo. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer´s disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24h. OUR results are as follow: (i) fluorescence of semples without nanopparticles was significantly highter in both older groups. ( old controls and people with Alzheimer´s diseases) than in those of younger (young controls and people with multiplesclerosis).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NS10369" target="_blank" >NS10369: Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer´s disease</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biosystems

ISSN

1742-206X

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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