Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F10%3A00001075" target="_blank" >RIV/00023752:_____/10:00001075 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/10:00002448

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease

Original language description

It is well known that oligomeric/aggregated amyloid ß peptides are a key player in the pathogenesis of Alzheimer disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. In the study, Thioflavin Tbased fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24 hours. Our results are as follows: i) fluorescenceof samples without nanoparticles was significantly higher in both older groups (old controls and people with Alzheimer disease) than in those of younger (young controls and people with multiple sclerosis), ii) nanoparticles did not markedly influence afluorescence intensity in young people but eliminated it in both old groups; nevertheless, the effects of nanoparticles were significantly lower in patients with Alzheimer disease then in the age-matched controls, and finally iii) signifi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biosystems

ISSN

1742-206X

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

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UT code for WoS article

000282765000013

EID of the result in the Scopus database

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