High leukocyte count and interleukin-10 predict high on-treatment-platelet-reactivity in patients treated with clopidogrel

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F12%3A43901485" target="_blank" >RIV/00064173:_____/12:43901485 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/12:43901485
Result on the web
<a href="http://dx.doi.org/10.1007/s11239-011-0659-5" target="_blank" >http://dx.doi.org/10.1007/s11239-011-0659-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11239-011-0659-5" target="_blank" >10.1007/s11239-011-0659-5</a>

Result language
angličtina
Original language name
High leukocyte count and interleukin-10 predict high on-treatment-platelet-reactivity in patients treated with clopidogrel
Original language description
According to recent trials, a significant number of patients do not have a completely effective response to clopidogrel. The aim of the study was to evaluate the rate of clopidogrel resistance in the context of important clinical characteristics and to specifically determine the relation between clopidogrel efficacy and biomarkers of inflammation. Consecutive non-selected patients following PCI were enrolled into the study. All patients received a loading dose of 600 mg of clopidogrel. The effect of clopidogrel was assessed using the VerifyNow assay 24 h after clopidogrel administration, clopidogrel resistance was defined as PRU 240. At the same time, standard parameters of biochemistry and hematology, the concentration of anti-inflammatory cytokine interleukin-10 and of soluble CD40 ligand, were measured. 378 patients were enrolled. 243 (64.3%) patients were responders (R) and 135 patients (35.7%) were non-responders (NR). Non-responders were older (R 65.7 - 13.3, NR 69.8- 11.5, P < 0
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/NS9988" target="_blank" >NS9988: Resistance to antiplatelet agents, its etiology and the possibility of its affection</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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