Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F14%3A%230000390" target="_blank" >RIV/00064173:_____/14:#0000390 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/jcmm.12310" target="_blank" >http://dx.doi.org/10.1111/jcmm.12310</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jcmm.12310" target="_blank" >10.1111/jcmm.12310</a>

Result language
angličtina
Original language name
Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease
Original language description
Patients with alcoholic liver disease (ALD) often display disturbed iron indices. Hepcidin, a key regulator of iron metabolism, has been shown to be down-regulated by alcohol in cell lines and animal models. This down-regulation led to increased duodenaliron transport and absorption in animals. In this study, we investigated gene expression of duodenal iron transport molecules and hepcidin in three groups of patients with ALD (with anaemia, with iron overload and without iron overload) and controls. Expression of DMT1, FPN1, DCYTB, HEPH, HFE and TFR1 was measured in duodenal biopsies by using real-time PCR and Western blot. Serum hepcidin levels were measured by using ELISA. Serum hepcidin was decreased in patients with ALD. At the mRNA level, expressions of DMT1, FPN1 and TFR1 genes were significantly increased in ALD. This pattern was even more pronounced in the subgroups of patients without iron overload and with anaemia. Protein expression of FPN1 paralleled the increase at the mR
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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