Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43900089" target="_blank" >RIV/00216208:11120/12:43900089 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/12:10106650 RIV/00064173:_____/12:43900089
Result on the web
<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01458.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2011.01458.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01458.x" target="_blank" >10.1111/j.1582-4934.2011.01458.x</a>
Alternative languages
Result language
angličtina
Original language name
Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency
Original language description
Disturbances of iron metabolism are observed in chronic liver diseases. In the present study, we examined gene expression of duodenal iron transport molecules and hepcidin in patients with hereditary hemochromatosis (HHC) (treated and untreated), involving various genotypes (genotypes which represent risk for HHC were examined), and in patients with iron deficiency anemia (IDA). Gene expressions of DMT1, ferroportin, Dcytb, hephaestin, HFE, and TFR1 were measured in duodenal biopsies using real-time PCRand Western blot. Serum hepcidin levels were measured using ELISA. DMT1, ferroportin, and TFR1 mRNA levels were significantly increased in post-phlebotomized hemochromatics relative to controls. mRNAs of all tested molecules were significantly increasedin patients with IDA compared to controls. The protein expression of ferroportin was increased in both groups of patients but not significantly. Spearman rank correlations showed that DMT1 vs. ferroportin, Dcytb vs. hephaestin and DMT1 v
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
1816-1826
UT code for WoS article
000306909200019
EID of the result in the Scopus database
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