Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10293820" target="_blank" >RIV/00216208:11140/14:10293820 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/14:10293820 RIV/00216208:11120/14:43908521

Result on the web

<a href="http://dx.doi.org/10.1111/jcmm.12310" target="_blank" >http://dx.doi.org/10.1111/jcmm.12310</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jcmm.12310" target="_blank" >10.1111/jcmm.12310</a>

Result language

angličtina

Original language name

Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease

Original language description

Patients with alcoholic liver disease (ALD) often display disturbed iron indices. Hepcidin, a key regulator of iron metabolism, has been shown to be down-regulated by alcohol in cell lines and animal models. This down-regulation led to increased duodenaliron transport and absorption in animals. In this study, we investigated gene expression of duodenal iron transport molecules and hepcidin in three groups of patients with ALD (with anaemia, with iron overload and without iron overload) and controls. Expression of DMT1, FPN1, DCYTB, HEPH, HFE and TFR1 was measured in duodenal biopsies by using real-time PCR and Western blot. Serum hepcidin levels were measured by using ELISA. Serum hepcidin was decreased in patients with ALD. At the mRNA level, expressions of DMT1, FPN1 and TFR1 genes were significantly increased in ALD. This pattern was even more pronounced in the subgroups of patients without iron overload and with anaemia. Protein expression of FPN1 paralleled the increase at the mR

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cellular and Molecular Medicine [online]

ISSN

1582-4934

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

1840-1850

UT code for WoS article

000342980100014

EID of the result in the Scopus database

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