Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00000488" target="_blank" >RIV/00216208:11120/09:00000488 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess
Original language description
The aim of this study was to compare the expression of proteins potentially involved in non-transferrin iron transport across membranes (DMT1, Dcytb, ferroportin, hephaestin, and ceruloplasmin) in various types of human cells (Caco-2, K562 and HEP-G2) under extracellular iron deficiency and excess of extracellular non-transferrin iron. We demonstrated that changes in iron availability, i.e. iron deficiency and iron excess, affect the expression of DMT1, Dcytb, ferroportin, hephaestin and ceruloplasmin on mRNA as well as on protein level in a cell type-specific manner.
Czech name
Rozdílná exprese genů zúčastněných v transportu netransferinového železa přes plazmatickou membránu u různých typů buněk pod vlivem deprivace a nadbytku železa
Czech description
Cílem práce bylo porovnat expresi proteinů účastnících se transportu netransferinového železa přes membrány (DMT1, Dcytb, ferroportin, hephaestin, a ceruloplasmin) u různých typů lidských buněk (Caco-2, K562 and HEP-G2) pod vlivem deprivace a nadbytku extracelulárního netransferinového železa. Ukázali jsme, že změny v dostupnosti železa, tj. deprivace železa a nadbytek železa, ovlivňují expresi DMT1, Dcytb, ferroportinu, hephaestinu a ceruloplasminu na úrovni mRNA i proteinů v závislosti na daném typu buněk.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Biochemistry
ISSN
0300-8177
e-ISSN
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Volume of the periodical
321
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
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UT code for WoS article
000262402500013
EID of the result in the Scopus database
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