Is colorectal cancer a more aggressive disease in young patients? A population-based study from the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F19%3AN0000095" target="_blank" >RIV/00064173:_____/19:N0000095 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00112407 RIV/00216208:11120/19:43918913 RIV/00216208:11130/19:10399304 RIV/00064203:_____/19:10399304

Result on the web

<a href="https://doi.org/10.1016/j.canep.2019.101621" target="_blank" >https://doi.org/10.1016/j.canep.2019.101621</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canep.2019.101621" target="_blank" >10.1016/j.canep.2019.101621</a>

Result language

angličtina

Original language name

Is colorectal cancer a more aggressive disease in young patients? A population-based study from the Czech Republic

Original language description

INTRODUCTION: The incidence of colorectal cancer in young patients is increasing. The goal of this study was to investigate whether clinicopathological features and survival differed between young, middle-aged and elderly patients. METHODS: The Czech National Cancer Registry was searched to identify all cases of colorectal cancer between 1982 and 2014. Three subgroups of patients were created: young patients, defined as being between 18 and 40 years of age, middle-aged patients, defined as being between 41 and 74 years of age, and elderly patients, defined as being over the age of 75 years. RESULTS: A total of 192,241 patients diagnosed with colorectal cancer between the years 1982 and 2014 were included in the study. Out of these, 3,287 patients (1.7%) were between 18 and 40 years of age, 134,139 patients (69.8%) were between 41 and 74 years of age and 54,815 patients (28.5%) were 75 years of age or older. The young patients had a higher incidence of mucinous adenocarcinoma and signet ring cell carcinoma, more advanced disease and more rectal tumours than elderly patients. Nonetheless, young patients received treatment more frequently and had better cancer-specific survival than the older patients. CONCLUSION: The better prognosis in young patients is presumably due to their better physiological reserve and lower incidence of comorbidities. Efforts should be made in younger patients to diagnose early and treat aggressively.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Epidemiology

ISSN

1877-7821

e-ISSN

1877-783X

Volume of the periodical

63

Issue of the periodical within the volume

December

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

Article 101621

UT code for WoS article

000504659600021

EID of the result in the Scopus database

2-s2.0-85073504002