Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F19%3AN0000151" target="_blank" >RIV/00064173:_____/19:N0000151 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/19:43919237 RIV/00216208:11130/19:10401711 RIV/00216208:11140/19:10401711 RIV/00216208:11150/19:10401711 and 3 more

Result on the web

<a href="https://doi.org/10.1186/s40425-019-0781-z" target="_blank" >https://doi.org/10.1186/s40425-019-0781-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40425-019-0781-z" target="_blank" >10.1186/s40425-019-0781-z</a>

Result language

angličtina

Original language name

Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients

Original language description

BACKGROUND: Adjuvanticity, which is the ability of neoplastic cells to deliver danger signals, is critical for the host immune system to mount spontaneous and therapy-driven anticancer immune responses. One of such signals, i.e., the exposure of calreticulin (CALR) on the membrane of malignant cells experiencing endoplasmic reticulum (ER) stress, is well known for its role in the activation of immune responses to dying cancer cells. However, the potential impact of CALR on the immune contexture of primary and metastatic high-grade serous carcinomas (HGSCs) and its prognostic value for patients with HGSC remains unclear. METHOD: We harnessed a retrospective cohort of primary (no = 152) and metastatic (no = 74) tumor samples from HGSC patients to investigate the CALR expression in relation with prognosis and function orientation of the tumor microenvironment. IHC data were complemented with transcriptomic and functional studies on second prospective cohort of freshly resected HGSC samples. In silico analysis of publicly available RNA expression data from 302 HGSC samples was used as a confirmatory approach. RESULTS: We demonstrate that CALR exposure on the surface of primary and metastatic HGSC cells is driven by a chemotherapy-independent ER stress response and culminates with the establishment of a local immune contexture characterized by T1 polarization and cytotoxic activity that enables superior clinical benefits. CONCLUSIONS: Our data indicate that CALR levels in primary and metastatic HGSC samples have robust prognostic value linked to the activation of clinically-relevant innate and adaptive anticancer immune responses.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal for ImmunoTherapy of Cancer

ISSN

2051-1426

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

November

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

Article 312

UT code for WoS article

000501331700001

EID of the result in the Scopus database

2-s2.0-85075465901