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Whole genome sequencing of macrolide resistant Streptococcus pneumoniae serotype 19A sequence type 416

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F20%3AN0000200" target="_blank" >RIV/00064173:_____/20:N0000200 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/20:43920315 RIV/00216208:11150/20:10412967 RIV/00179906:_____/20:10412967 RIV/75010330:_____/20:00013024 RIV/00216208:11140/20:10412967

  • Result on the web

    <a href="https://doi.org/10.1186/s12866-020-01909-1" target="_blank" >https://doi.org/10.1186/s12866-020-01909-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s12866-020-01909-1" target="_blank" >10.1186/s12866-020-01909-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Whole genome sequencing of macrolide resistant Streptococcus pneumoniae serotype 19A sequence type 416

  • Original language description

    BACKGROUND: The resistance of Streptococcus pneumoniae to macrolides is becoming an increasingly important issue and thus it is important to understand the genetics related to adaptation of this species to the widespread use of antibiotics in Europe. The 58 isolates of S. pneumoniae belonging to sequence type (ST) 416 and serotype 19A and to several different phenotypes originated from Italy, Portugal and Czech Republic were thus sequenced on Illumina MiSeq. The aim of the study was to describe genetical origine of isolates, investigate their macrolide resistance and suggest reasons for spread of ST416 in the Czech Republic. RESULTS: Investigation of genes associated with serotype determined serotype switch between 15B and 19A serotypes and core genome multilocus sequence typing (cgMLST) confirmed the origine of concerned isolates in Netherlands-37 clone. Inspected genomes proved variability of genes associated with the macrolide resistance even within closely genetically relative isolates. CONCLUSIONS: Participation of 19A/ST416 on the spread of Netherlands-37 is accompanied by serotype switch between 19A and 15B serotypes and with acquisition of genes involved in macrolide resistance to the clone that was originally macrolide susceptible. There is evident tendency to interchanging and modifications of these and surrounding genes, that could lead to accelerate spreading of this sequence type in regions with high macrolide consumption.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BMC Microbiology

  • ISSN

    1471-2180

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    July

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    224

  • UT code for WoS article

    000555944000002

  • EID of the result in the Scopus database

    2-s2.0-85088622988