Alteration of cortical but not spinal inhibitory circuits in idiopathic scoliosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43920010" target="_blank" >RIV/00064173:_____/22:43920010 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/22:43920010 RIV/00216208:11320/22:10410223

Result on the web

<a href="https://doi.org/10.1080/10790268.2020.1739893" target="_blank" >https://doi.org/10.1080/10790268.2020.1739893</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10790268.2020.1739893" target="_blank" >10.1080/10790268.2020.1739893</a>

Result language

angličtina

Original language name

Alteration of cortical but not spinal inhibitory circuits in idiopathic scoliosis

Original language description

The pathogenesis of adolescent idiopathic scoliosis (AIS), including the role of brain and spinal inhibitory circuits, is still poorly elucidated. The aim of this study was to identify which central inhibitory mechanisms are involved in the pathogenesis of AIS. A prospective neurophysiological study, using a battery of neurophysiological tests, such as cutaneous (CuSP) and cortical (CoSP) silent periods, motor evoked potentials (MEP) and paired-pulse transcranial magnetic stimulation (ppTMS). Neurophysiological laboratory. Sixteen patients with AIS (14 females, median age 14.4) and healthy controls. MEPs were obtained after transcranial magnetic stimulation (TMS) and recorded from the abductor pollicis muscle (APB). ppTMS was obtained at interval ratios (ISI) of 1, 2, 3, 6, 10, 15 and 20 ms. The cortical silent period (CoSP) was recorded from the APB. The cutaneous silent period (CuSP) was measured after painful stimuli delivered to the thumb while the subjects maintained voluntary contraction of the intrinsic hand muscles. The data were analyzed and compared with those from healthy subjects. The CoSP duration was significantly prolonged in AIS patients. A significantly higher amplitude of ppTMS for ISI was found in all AIS patients, without remarkable left-right side differences. No significant difference in MEP latency or amplitude nor in the CuSP duration was obtained. Our observation demonstrates evidence of central nervous system involvement in adolescent idiopathic scoliosis (AIS). Lower intracortical inhibition, higher motor cortex excitability, and preserved spinal inhibitory circuits are the main findings of this study. A possible explanation of these changes could be attributed to impaired sensorimotor integration predominantly at the cortical level.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Spinal Cord Medicine

ISSN

1079-0268

e-ISSN

2045-7723

Volume of the periodical

45

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

186-193

UT code for WoS article

000524729900001

EID of the result in the Scopus database

2-s2.0-85082427260