Pallidal stimulation in dystonia affects cortical but not spinal inhibitory mechanisms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F16%3A%230006958" target="_blank" >RIV/00023884:_____/16:#0006958 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/16:43912164 RIV/00064173:_____/16:N0000104 RIV/00216208:11110/16:10328064 RIV/00064165:_____/16:10328064

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Pallidal stimulation in dystonia affects cortical but not spinal inhibitory mechanisms

Original language description

BACKGROUND: Deep brain stimulation (DBS) of the globus pallidus interna is an effective tool for the treatment of dystonia with possible distant effects reaching beyond the basal ganglia network. AIM: We analyzed the cortical silent period (CoSP) to test inhibitory circuits at the cortical level, and the cutaneous silent period (CuSP) and the H-reflex to test inhibitory circuits at the spinal level. METHODS: The upper limb muscles of 16 patients (9F, aged 54 (SD)16years) with generalized (N=9) and cervical (N=7) dystonia treated with DBS bilaterally were examined by the CoSP, CuSP and H-reflex in two states with random order: (i) in DBS ON and (ii) in DBS OFF condition two hours later, and compared with healthy controls. RESULTS: While the CuSP and H-Reflex did not differ between groups and remained unaffected by DBS, the CoSP was influenced significantly in dystonia. The CoSP onset latency was shortened (p<0.05 corrected) and the CoSP duration prolonged (p<0.01 corrected) in ON versus OFF condition. This effect was especially larger in generalized or phasic type of dystonia. Compared to healthy controls, the CoSP latency and duration became shorter in patients during the OFF condition only. CONCLUSION: The pallidal DBS did not affect the spinal inhibitory circuitry in dystonia. However, the abnormally low cortical inhibition was normalized after DBS possibly offering more efficient suppression of aberrant dystonic movements.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT12282" target="_blank" >NT12282: Pathophysiological mechanisms of neuromodulation therapy in dystonia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurological Sciences

ISSN

0022-510X

e-ISSN

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Volume of the periodical

369

Issue of the periodical within the volume

Oct 15

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

19-26

UT code for WoS article

000384861000005

EID of the result in the Scopus database

2-s2.0-84982719018