Systematic analysis of mucosal-associated invariant T cells in haematological malignancies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926893" target="_blank" >RIV/00064173:_____/24:43926893 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/24:43926893 RIV/00216208:11310/24:10478952

Result on the web

<a href="https://doi.org/10.1111/sji.13364" target="_blank" >https://doi.org/10.1111/sji.13364</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sji.13364" target="_blank" >10.1111/sji.13364</a>

Result language

angličtina

Original language name

Systematic analysis of mucosal-associated invariant T cells in haematological malignancies

Original language description

Mucosal-associated invariant T-cells (MAIT) are unconventional T-cells with cytotoxic and pro-inflammatory properties. Previous research has reported contradictory findings on their role in cancerogenesis with data being even scarcer in haematological malignancies. Here, we report the results of a systematic analysis of MAIT cells in treatment-naive patients with a broad range of haematological malignancies. We analysed peripheral blood of 204 patients and 50 healthy subjects. The pool of haematological patients had a statistically significant lower both the absolute value (median values, 0.01 x 109/L vs. 0.05 x 109/L) of MAIT cells and their percentage (median values 0.94% vs. 2.56%) among T-cells compared to the control group. Separate analysis showed that the decrease in the absolute number of MAIT cells is significant in patients with acute myeloid leukaemia, myeloproliferative neoplasms, plasma cell myeloma, B-cell non-Hodgkin lymphomas, otherwise not specified, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma compared to the control population. Furthermore, in haematological malignancies, MAIT cells overexpress PD-1 (average values, 51.7% vs. 6.7%), HLA-DR (average values, 40.2% vs. 7%), CD38 (average values, 25.9% vs. 4.9%) and CD69 (average values, 40.2% vs. 9.2%). Similar results were obtained when comparing patients with individual malignancies to the control population. Our data show that the depletion of circulating MAIT cells is a common observation in a broad spectrum of haematological malignancies. In addition to their reduced numbers, MAIT cells acquire an activated/exhausted phenotype. Circulating Mucosal-associated invariant T-cells (MAIT) cells are significantly depleted in a broad spectrum of treatment-naive haematological malignancies compared to sex and age-matched healthy subjects. In addition to their reduced numbers, MAIT cells acquire an activated/exhausted phenotype characterized by higher expression of HLA-DR, CD69, CD38 and PD-1.image

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scandinavian Journal of Immunology

ISSN

0300-9475

e-ISSN

1365-3083

Volume of the periodical

99

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

"e13364"

UT code for WoS article

001178750800001

EID of the result in the Scopus database

2-s2.0-85186850742