Vulvar and vaginal cancer during pregnancy: A pooled analysis of 15 cases from the International Network on Cancer, Infertility and Pregnancy and review of the literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928833" target="_blank" >RIV/00064173:_____/25:43928833 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/25:43928833

Result on the web

<a href="https://doi.org/10.1111/aogs.70044" target="_blank" >https://doi.org/10.1111/aogs.70044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/aogs.70044" target="_blank" >10.1111/aogs.70044</a>

Result language

angličtina

Original language name

Vulvar and vaginal cancer during pregnancy: A pooled analysis of 15 cases from the International Network on Cancer, Infertility and Pregnancy and review of the literature

Original language description

Introduction Vulvovaginal cancer in pregnancy is rare. Limited data complicate decision-making and patient counseling. Our review, coupled with new case data, fills a current gap in the literature and provides practical insights.Material and Methods Oncological and obstetric data of these pregnancies were examined by a case collection from the International Network on Cancer, Infertility and Pregnancy (INCIP) registry (vulvar n = 10, vaginal n = 5) and a literature review (vulvar n = 46, vaginal n = 37).Results Although preoperative imaging of inguinofemoral lymph nodes is feasible, only 16.1% of vulvar cancer patients underwent ultrasound or MRI. Treatment was initiated during pregnancy for 69.1% of vulvar cancer and 28.4% of vaginal cancer patients. Surgical lymph node staging of vulvar cancer was postponed until after delivery in 10 cases, although uni- or bilateral lymphadenectomy during pregnancy was not associated with more complications. Delivery outcomes included a live birth rate of 96.4% for vulvar cancer and 50% for vaginal cancer due to the high rate of pregnancy terminations, with most births preterm. The overall 5-year survival rates for vulvar (81.3%) and vaginal (66.4%) cancer during pregnancy are comparable to nonpregnant populations, indicating that pregnancy does not adversely impact maternal prognosis.Conclusions This study underscores the feasibility of adapting standard oncological care for pregnant patients, emphasizing multidisciplinary teams to optimize maternal and fetal outcomes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Obstetricia et Gynecologica Scandinavica

ISSN

0001-6349

e-ISSN

1600-0412

Volume of the periodical

104

Issue of the periodical within the volume

11

Country of publishing house

DK - DENMARK

Number of pages

13

Pages from-to

2187-2199

UT code for WoS article

001567339800001

EID of the result in the Scopus database

2-s2.0-105015515133