Short-course whole-brain radiotherapy (WBRT) for brain metastases due to small-cell lung cancer (SCLC)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A10294187" target="_blank" >RIV/00064203:_____/10:10294187 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/10:10294187
Result on the web
<a href="http://dx.doi.org/10.1016/j.clineuro.2009.11.004" target="_blank" >http://dx.doi.org/10.1016/j.clineuro.2009.11.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clineuro.2009.11.004" target="_blank" >10.1016/j.clineuro.2009.11.004</a>
Alternative languages
Result language
angličtina
Original language name
Short-course whole-brain radiotherapy (WBRT) for brain metastases due to small-cell lung cancer (SCLC)
Original language description
Objective: Many patients with brain metastases due to SCLC have a poor survival prognosis. The most common treatment is whole-brain radiotherapy (WBRT). This retrospective study compares short-course WBRT with 5 x 4 Gy in 1 week to standard WBRT with 10x 3 Gy in 2 weeks. Methods: Forty-four SCLC patients receiving WBRT with 5 x 4 Gy were compared to 102 patients receiving 10 x 3 Gy for survival (OS) and local (intracerebral) control (LC). Seven further potential prognostic factors were investigated: age, gender, Karnofsky Performance Score (KPS), number of brain metastases, extracerebral metastases, interval from tumor diagnosis to WBRT, RPA (Recursive Partitioning Analysis) class. Results: After 5 x 4 Gy, 12-month OS was 15%, versus 22% after 10 x 3Gy (p = 0.69). On multivariate analysis, improved OS was associated with age {= 60 years (p = 0.013), KPS }= 70 (p < 0.001). <4 brain metastases (p = 0.011), and RPA class 1 (p < 0.001). 12-month LC was 34% after 5 x 4 Gy versus 25% after
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurology and Neurosurgery
ISSN
0303-8467
e-ISSN
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Volume of the periodical
112
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
183-187
UT code for WoS article
000276049900002
EID of the result in the Scopus database
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