Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A10294184" target="_blank" >RIV/00064203:_____/12:10294184 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:10294184
Result on the web
<a href="http://dx.doi.org/10.1002/cncr.26680" target="_blank" >http://dx.doi.org/10.1002/cncr.26680</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cncr.26680" target="_blank" >10.1002/cncr.26680</a>
Alternative languages
Result language
angličtina
Original language name
Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
Original language description
BACKGROUND: Patients with brain metastases who have a favorable survival prognosis may benefit from intensive treatments, including neurosurgery and radiosurgery. However, many patients cannot receive such treatments, and whole-brain radiotherapy (WBRT)alone is their only option. The most common WBRT schedule is 30 grays (Gy) in 10 fractions. In this retrospective study, the authors investigated whether these patients benefit from a dose escalation beyond 30 Gy. METHODS: Data from 109 patients who received 30 Gy in 10 fractions were compared with 75 patients who received 40 Gy in 20 fractions. All patients had a favorable survival prognosis. Both groups were compared for local control (LC) and overall survival (OS). Subgroup analyses were performed for patients who had less radiosensitive tumors (N = 27) and for other patients (N = 157). RESULTS: The LC rate at 1 year was 28% after 30 Gy and 44% after 40 Gy (P = .064). On multivariate analysis, the 40 Gy dose was associated with impro
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer
ISSN
0008-543X
e-ISSN
—
Volume of the periodical
118
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
3852-3859
UT code for WoS article
000306671300024
EID of the result in the Scopus database
—